Cutting-edge Brain Signal Technology Developed by Korean Scientists
Busan, Wednesday, 11 June 2025.
Researchers at Busan National University have created a flexible neural probe that measures and stimulates brain signals, significantly reducing immune response and enhancing neuroscience applications.
Revolutionizing Brain-Computer Interfaces
In a groundbreaking study, Professors Hong Seok-won and Shin Hwa-kyung from Busan National University have developed an ultrathin neural probe designed for real-time measurement and stimulation of brain signals. This development signifies a major stride in the field of flexible electronic devices, aimed at enhancing the efficacy of brain-computer interfaces (BCIs) [1].
Innovative Design and Applications
The neural probe, with a thickness of just 3.6 micrometers, can record up to 32 channels of high-resolution electrophysiological signals from deep within the mouse brain. Coupled with its design to enable deep brain stimulation, the technology offers simultaneous signal measurement and therapeutic application [2]. By utilizing a ‘kirigami’ micro-cutting technique, the probe achieves flexibility to adapt smoothly to brain micro-movements, thereby improving the reliability of long-term neurological studies [1][2].
Safety and Biocompatibility
To address issues of biocompatibility, the probe’s surface is coated with laminin, a component that reduces immune responses when implanted in neural tissues. Experimental results demonstrated a substantial decrease in inflammatory markers such as IBA-1 and GFAP by approximately 25-30%, alongside a reduction in reactive oxygen species in brain immune cells [3]. This enhancement is pivotal for long-term stability and functionality of neural implants, especially in therapeutic contexts like Parkinson’s disease [1][2].
Future Prospects
The flexible neural probe can potentially be expanded into a comprehensive brain research platform by incorporating optical fibers, drug delivery channels, and wireless power transfer. Such integration could revolutionize the way neural interfaces interact with biological systems, marking a significant leap toward more personalized and minimally invasive medical treatments [2].